We achieved more than a 20-fold improvement in protein production through strain development compared with the original strain.
Case example
We aim to enhance target product productivity through the diversification and optimization of expression-related factors, enzyme function improvement, and strain improvement using Disparity Mutagenesis.
Our solution
Our solution
Through strain development, we reduced foaming and vessel adhesion in a filamentous fungal strain. We also have a track record of improving a wide range of other strain characteristics.
Case example
Through strain development, we develop strains with improved characteristics while maintaining their production capabilities. This enables us to introduce strain characteristics that are difficult to achieve through genetic design alone.
Strain Characteristic and Performance Enhancement
Address Cultivation Challenges such as Foaming and High Broth Viscosity.
Improve the Yield and Productivity of Target Products by Modifying Microorganisms
Production Yield Enhancement
CASE STUDY
By-Product Reduction
Reduce By-Products to Improve Yield and Target Product Purification Efficiency
Our solution
Through strain development, we increased product production by more than 2.5-fold compared with the parent strain, while reducing by-product formation to approximately 25% of the level observed in the parent strain.
Case example
We aim to reduce by-products through expression regulation and strain improvement using Disparity Mutagenesis. This can improve target product yield from sugar (substrate conversion efficiency) and reduce costs associated with separation and purification.
Strain Development for New Bioproduction Applications
Developing Strains for Target Product Production, from Metabolic Pathway Design to Strain Improvement
Our solution
We combine metabolic pathway design, expression optimization, and strain improvement to introduce new functions into a host and develop production strains.
Works Across a Wide Range of Species
Strain improvement using Disparity Mutagenesis can be applied to a wide range of species.
Our solution
Disparity Mutagenesis can be applied to a wide range of organisms, including microorganisms, microalgae, animal cells, and plants. In particular, we have extensive experience applying the method to microorganisms, from prokaryotic to eukaryotic microorganisms. Across these strains, we have achieved higher mutation rates and higher survival rates than with conventional methods.